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Biophysical meeting in San Diego

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Attending conferences is an important part of the scientific research. It represent the  the possibility to share information even before they reached definitive publishable results, to be updated about the most recent discoveries directly by the authors, to do networking and have informal discussions with people who do the same research as you, but differently, and last but not least... it push you to travel around the world! (Incidentally, from Osaka the shortest route is via the Hawaii, where I will stop by few days in the way back). As part of my project, I am going to San Diego (CA) to attend the Biophysical Society Annual Meeting, a five-day meeting with about 5,000 attendees,  500 speakers and 600 daily poster presentations, included mine. I will present an analysis about the calcium gradients in resting muscle cells generated by the leakage of the calcium-release channel. The channel (RyR) functionally opens during action potentials to release big a...
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Your own project, your own life!!

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Probably, the best way to start this blog is... from the beginning. I arrived in Japan in September 2021 as the outgoing period of a Global Fellowship project which has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 886232 and here I will shortly describe the project aims. First, the Global Fellowship are grants "open to European nationals or long-term residents who wish to engage in R&I projects with organisations outside EU Member States" These fellowships require an outgoing phase of minimum 12 and maximum 24 months , as in my case, in a non-associated Third Country. For the reason outlined below, I chose JAPAN 🇯🇵 as hosting country . After the outgoing period there is a mandatory 12-month return phase to a host organisation based in an EU Member State which in my case is ITALY 🇮🇹. The hosting organizations are RIKEN in Japan, and Padova University in Italy. My p...
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Role of mitochondria on the Calcium diffusion inside a muscle cell

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How important is the calcium diffusion in the sequential activation of the thick filament? I discussed about this topic in a previous post . With my collaborators at the Department of Biomedical Science s in Padova University, we are exploring this issue through a mathematical model based on experimental data on calcium signalling in the three main compartments of the muscle cells: sarcoplasmic reticulum, cytosol and mitoshondria. In fact, while usually neglected, we think that mithocondria may play an important role in the calcium distribution during activation, at least in skeletal muscle cells. Our work lead to an extensive review done with the priceless enormous contribution of Prof. Carlo Reggiani, just published in the Journal of General Physiology.  You can read it here , but our main conclusion is that the mitochondria may have an important role, and that this must be elucidated with further analyses.  From the point of view of the super relaxed state, and its activati...
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