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Heart Fi-Re: HEART FIne REgulation through mechanosensing in myosin filaments: merging theory and experiments into a multi-scale heart simulator
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Old posts will be published again soon. New posts will be sometime published in the meantime.
How important is the calcium diffusion in the sequential activation of the thick filament? I discussed about this topic in a previous post . With my collaborators at the Department of Biomedical Science s in Padova University, we are exploring this issue through a mathematical model based on experimental data on calcium signalling in the three main compartments of the muscle cells: sarcoplasmic reticulum, cytosol and mitoshondria. In fact, while usually neglected, we think that mithocondria may play an important role in the calcium distribution during activation, at least in skeletal muscle cells. Our work lead to an extensive review done with the priceless enormous contribution of Prof. Carlo Reggiani, just published in the Journal of General Physiology. You can read it here , but our main conclusion is that the mitochondria may have an important role, and that this must be elucidated with further analyses. From the point of view of the super relaxed state, and its activati...
Attending conferences is an important part of the scientific research. It represent the the possibility to share information even before they reached definitive publishable results, to be updated about the most recent discoveries directly by the authors, to do networking and have informal discussions with people who do the same research as you, but differently, and last but not least... it push you to travel around the world! (Incidentally, from Osaka the shortest route is via the Hawaii, where I will stop by few days in the way back). As part of my project, I am going to San Diego (CA) to attend the Biophysical Society Annual Meeting, a five-day meeting with about 5,000 attendees, 500 speakers and 600 daily poster presentations, included mine. I will present an analysis about the calcium gradients in resting muscle cells generated by the leakage of the calcium-release channel. The channel (RyR) functionally opens during action potentials to release big a...
Ready to start! For two days the university of Padova will share the science with the non university public in Padova. I contributed to a very nice event organized by the Department of Biomedical Sciences, to extract the DNA from a... banana! I saw many young reserachers (7-12 years old) interested and excited to destroy the banana cells and to so a loooong DNA emerging into the solution. It is a very easy experience that everyone can do at home with common items, just dish soap, salt, water and "pink" alchool. But if you want to know the procedure you had better to come to the event and listen the nice explanation of Giorgia! Every young scientist had the possibility to bring the DNA home.
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