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Heart Fi-Re: HEART FIne REgulation through mechanosensing in myosin filaments: merging theory and experiments into a multi-scale heart simulator
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Old posts will be published again soon. New posts will be sometime published in the meantime.
One thing I like of Japan is it's natural landscapes. And coming from a superflat region in Italy, where the highest point doesn't overcome (maybe) 10 meters above sea level and the lowest is few meters below, I really like mountains and hiking. Before leaving Japan, I decided that I MUST climb Fuji san! It's the highest mountain in Japan and it's also a volcano. And a sacred mountain as well (the name derive from Fuchi, the Ainu's god of fire), but I am more on the hiking side! Here I am on the shinkansen to Shizuoka. It takes just a couple of hours from my house to this bullet train running at 280 km/hour now. Then a slower train will bring me in 90 minutes at about 35 km from the top. Then I hope to walk for about 15 hours to reach the top in time for the sunset!
Let me introduce shortly the project. The main reason why I am living in Japan now. The super short story, is that a new state has been “recently” discovered in the striated muscle. A state which is stable in the relaxed muscles , which was hiding itself because for many decades researchers were interested in the active behavior of muscles . It’s obvious isn’t it? You want to know how muscle contract, not how the can stay relaxed!! Well, the current view is that this new state, called SUPER-RELAXED STATE , can deeply influence the active behavior of muscles, especially of cardiac muscle, causing also serious diseases when it’s equilibrium is perturbed . So, in this sense the super-relaxed state is pretty “active” or “genki” (げんき, or 元気) in Japanese. A 元気 super-relaxed state ! So! My Global Fellowship project aims at: (i) defining the theoretical bases of the recently discovered “mechanosensing” (MS) mechanism that a...
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